Volume 5, Issue 2

Relationship between Antioxidant Capacity and Food Chemistry
Original Research
A practical experiment devoted to study the properties of common foods (lemon, tea and garlic) containing antioxidant molecules is presently described. The experimental part was based on four main steps: (i) realization of calibration curves with standard antioxidants reacting with the 1,1-diphenyl-2-picryl-hydrazyl radical (DPPH•), (ii) quantitation of antioxidant molecules in food extracts, and (iii) determination of food extract antioxidant capacity vs. DPPH•, which (iv) was linked to the content of antioxidant molecules in each food extract. The educational approach was based on both conceptual thermodynamic processes and on practical knowledge on food chemistry and also diet related to healthcare. As a result, in addition to gain experience in simple spectroscopic methods, students went deeper in the understanding of the redox mechanisms devoted to oxidative stress basic learning.
World Journal of Chemical Education. 2017, 5(2), 78-85. DOI: 10.12691/wjce-5-2-7
Pub. Date: April 07, 2017
18686 Views2966 Downloads
The Analysis of Paracetamol – A Comparison between Electrochemistry, Electrochemiluminescence and GC-MSD
Original Research
We present two electrochemical methods—cyclic voltammetry and electrogenerated chemiluminescence—to qualitatively and quantitatively detect paracetamol, a pharmaceutical preparation. The results are compared to those achieved with GC-MSD.
World Journal of Chemical Education. 2017, 5(2), 37-45. DOI: 10.12691/wjce-5-2-3
Pub. Date: March 17, 2017
28844 Views4076 Downloads
Creating Unique Undergraduate Research Projects for Nursing Majors that Investigate the Anti-proliferative Effects of Heavy Metal Compounds on MCF-7, A375, and HFF Cells
Original Research
Heavy metals, such as thallium and barium, are known for their toxicity. The focus of this project was to create research techniques for undergraduate nursing majors who had only two semesters of chemistry laboratory experience. This study investigated the antiproliferative effects of thallium and barium salts on breast cancer cells (MCF-7), skin cancer cells (A375), and normal Human Foreskin Fibroblasts (HFF). The project was designed to provide a unique research opportunity for nursing majors having only two semesters of chemistry laboratory experience. Critical thinking in chemistry and its application to real life situations were key learning objectives in investigating the toxic effects of various metals compounds on biological cells. Thallium, barium, and potassium possess very similar atomic radii, resulting in the ability of Tl+and Ba2+ to easily enter the cell via the Na+/K+ pump. Cytotoxicity was monitored utilizing a Sulforhodamine B (SRB) assay. Results indicated cell death for MCF-7 (2 µM TlCH3COO, 75 µM TlNO3), A375 (100 µM TlCH3COO, 75 µM TlNO3), and HFF (100 µM TlCH3COO, 100 µM TlNO3). Remarkably, these cells tolerated 800 µM Ba(NO3)2. The procedure and techniques were designed to limit exposure to toxins and enhance the education of Walsh University’s nursing majors.
World Journal of Chemical Education. 2017, 5(2), 29-36. DOI: 10.12691/wjce-5-2-2
Pub. Date: March 13, 2017
17544 Views2988 Downloads2 Likes
Designing Exercises to Determine the Structural Formula of Organic Compounds Based on the Experimental Data
Original Research
This paper introduces the way to design exercises to determine the structural formula of organic compounds based on the experimental data. They are structure, physical properties, typical chemical properties, synthesis methods and application. From that the authors have built the scheme to design exercises. On that basis, the authors compiled some exercises which are used for teaching and learning organic chemistry in university and high school.
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World Journal of Chemical Education. 2017, 5(2), 23-28. DOI: 10.12691/wjce-5-2-1
Pub. Date: March 07, 2017
13275 Views2962 Downloads13 Likes