An Innovative Method Designed for the Synthesis of Some New Mixed Ligand Ni(II) Complexes Its Characterization and Applications

Jitendra M. Pawara^1, and Sunil S. Patil¹

¹Department of Chemistry, Changu Kana Thakur Arts Commerce and Science College (Autonomous), New Panvel, Maharashtra, India

Cite this paper

Jitendra M. Pawara and Sunil S. Patil. An Innovative Method Designed for the Synthesis of Some New Mixed Ligand Ni(II) Complexes Its Characterization and Applications. World Journal of Chemical Education. 2021; 9(2):50-56. doi: 10.12691/WJCE-9-2-3

Abstract

In the present work, a series of new mixed ligand Ni(II) complexes of the type [Ni(P)(L).2H₂O] have been synthesized by using 2-amino-6-methyl pyrimidine-4-ol (HP), a primary ligand and N- and O- donor amino acids (HL) secondary ligands. Synthesis of Ni(II) complexes has been carried out by thermal and microwave methods. Results show that complexes synthesized by the microwave method were more efficient than the thermal method. Preparation time in the microwave method was short (4-7 min.) as compared to the thermal method (45 min.). Additionally, the microwave technique gave a very high yield (90%) of the complexes. The prepared complexes were characterized by Gouy experiment, FTIR, elemental analysis, TGA, and DTA at room temperature. The complexes have shown considerable antimicrobial activities such as antifungal and antibacterial activity.

Keywords

Ni(II) complexes, 2-amino-6-methyl pyridine-4-ol, amino acids, microwave, antimicrobial activity

Copyright

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References

[1]	Crichton, R., Biological Inorganic Chemistry: A New Introduction to Molecular Structure and Function, Elsevier Science & Technology, 2nd edition, 2012.
[2]	Ragsdale, S. W.; “Nickel-based enzyme systems,” Journal of Biological Chemistry, 2009, 284(28), 18571-18575.
[3]	Hirsh, H.; Coen, M.H.; Mozer, M.C.; Hasha, R. and Flanagan, J.L; “Room service, AI-style,” IEEE intelligent systems, 2002, 14(2), 8-19.
[4]	T. Eckes, the Developmental Social Psychology of Gender, Lawrence Erlbaum, 2000. [E-book] Available: net Library e-book.
[5]	Brown, F.; Organic chemistry. Thomson Learning Inc., 2002. 1074.
[6]	Al-Salami, B. K.; Mohammed, A. H.; Asker, K. A.; Synthesis and characterization of new Schiff bases derived from 2-hydroxybenzaldehyde and amino acids and their vanadyl complexes. Res J Pharm Biol Chem, 2014, 5, 1457- 1472.
[7]	Lehinger A. L., Nelson cox D. L., and Cox, M. M., Freeman CBS W.H., New York USA, 3rd ed., (2005). 71-95.
[8]	Andrews, R. K., Blakeley, R. L., Zerner, B., in: H. Sigel, A. Sigel (Eds.), Marcel Dekker inc., New York. 1988. 23.
[9]	Monster, A., Second ed. of the amino acid, vol.-I Academic press Inc. New York. 1960. 19-21.
[10]	M. N. Hughes, the Inorganic chemistry of biological process. John Wiley and sons Newyork. 1981.
[11]	N. E Dixon, C. Gazzola, R. L. Blakeley and B. Zerner, J. Am. Chem. Soc. (1975). 97: 4131-41133.
[12]	L. N. Magner History of Medicine, Taylor & Francis Group, LLC: Boca Raton, FL.
[13]	Garg R, Saini MK, Fahmi N, Singh RV. Spectroscopic and biochemical studies of some manganese (II), oxovanadium (V) and dioxovanadium (VI) complexes S/O and N donor agents synthesized under microwave conditions. Transit Met Chem 2006. 3(7), 362.
[14]	R.V. Prasad., N.V. Thakkar.: J. Mol. Catal. 1994. (9) 92.
[15]	Mahajan K, Swami M, Singh RV. Microwave synthesis, spectral studies, antimicrobial approach, and coordination behavior of antimony (III) and bismuth (III) compounds with benzothiazoline. Russ J Coord Chem 2009. 35(85), 179.
[16]	Mohanan K, Kumari BS, Rijulal G. Microwave-assisted synthesis, spectroscopic, thermal and antifungal studies of some lanthanide (III) complexes with a heterocyclic bishydrazone. J Rare Earths 2008. 26(8), 16-21.
[17]	Sharma, K, Singh R, Fahmi N, Singh RV. Microwave-assisted synthesis, characterization and biological evaluation of palladium and platinum complexes with azomethines. Spectrochim Acta A Mol Biomol Spectrosc 2010. 75(7), 422.
[18]	Sun Y, Machala ML, Castellano FN. Controlled microwave synthesis of RuII synthons and chromophores relevant to solar energy conversion. Inorg Chim Acta 2010. (7) 363-283.
[19]	S.Arulmurugan, H.P. Kavitha and B.R. Venkatraman, Biological Activities of Schiff Base And Its Complexes, Rasayan Journal of Chemistry, 2010. 3, 385-410.
[20]	A.M.A-Dief and I.M.A. Mohamed, “A Review on Versatile Applications of Transition Metal Complexes Incorporating Schiff Bases,” Beni-Suef University Journal of Basic and Applied Sciences. 2015. 4(2), 119-133.
[21]	Silva C. M. D., Silva D. L. D., Modolo L. V., Alves R. B., Resende M. A. D., Martins C.V.B., And Fatima A.D., “Schiff Bases: A Short Review of Their Antimicrobial Activities Journal of Advanced Research, 2011. 2(1), 1-8.
[22]	Qi, G.F., Yang Z.Y., and Wang B. D., “Synthesis, Characterization And DNA-Binding Properties Of Zinc (II) And Nickel (II) Schiff Base Complexes,” Transition Metal Chemistry, 2007. 32(2), 233-239.
[23]	Weissberger A., Techniques of Organic Chemistry, 1955Vol. 7(2).
[24]	Perrin D.D., Perrin D.R., Armarego W.L.F.: Purification of Laboratory Chemicals, 2nd ed., Pergamon Press Ltd., Oxford 1980.
[25]	Vogel A.I.: Textbook of Practical Organic Chemistry, 5th ed., Longmans Green and Co. Ltd., London 1989.
[26]	Sunil S. Patil , Ganesh A. Thakur and Vishwanath R. Patil Acta Poloniae Pharmaceutica ñ Drug Research, 2009. 66(3), 271-277.
[27]	Patil S. The chemistry of carbon-nitrogen double bond. John Wiley and Sons Ltd, 1970.
[28]	Liberta, A. E., and West, D. X., “Antifungal and antitumor activity of heterocyclic thiosemicarbazones and their metal complexes: current status,” Biometals, 1992. 5 (2), 121-126.
[29]	R. K. Agarwal, L. Singh, and D. K. Sharma, “Synthesis, spectral and biological properties of copper (II) complexes of thiosemicarbazones of Schiff bases derived from 4-aminoantipyrine and aromatic aldehyde," Bioinorganic Chemistry and Applications, vol. 2006, Article ID 59509, 10.
[30]	Geary W.J.: Coord. Chem. Rev.1971. 81(7).
[31]	Tumer M.: Synth. React. Inorg. Met.-Org. Chem. 2000. 30, 1139.
[32]	Chakrawarti P.B., Khanna P.: J. Ind. Chem. Soc. 1985. 77, 23.
[33]	Beraldo H., Kainser S.M., Turner J.D., Billeh I.S., Ives J.S., West D.X.: Trans. Metal Chem. 2007. 22, 528.
[34]	Lever A.B.: J. Chem. Educ. 1974. 51, 612.
[35]	Islam M.S., Ahmed M.S., Pal S.C., Reza Y., Jesmine S.: Ind. J. Chem. 1995. 34(A), 816.
[36]	Panda S., Mishra R., Panda A.K., Satpathy K.C.: J. Ind. Chem. Soc. 1989. 66, 472.
[37]	Banerjee A.K., Prakash D., Roy S.K.: J. Ind. Chem. Soc. 1976. 53, 458.
[38]	Mohanan K., Thankarajan N.: J. Ind. Chem. Soc.1990. 7, 583.
[39]	Nakamoto K.: Lattice Water and Aqua and Hydroxo Complexes. in Infrared and Raman Spectra of Inorganic and Coordination Compounds. J. Wiley and Sons, New York 1986. 4, 227.
[40]	Thakur G.A., Shaikh M.M.: Acta Pol. Pharm. Drug Res. 2006. 63, 95.
[41]	Thakur G.A., Dharwadkar S.R., Shaikh M.M.: Thermal Study on Mixed Ligand Thorium (IV) Complexes, Proceedings of the 15th National Symposium on Thermal Analysis (THERMANS 2006). 2006. 399.
[42]	Harriet H., Djebbar-Sid S., Benali-Baitich O., Khan M.A., Bouet G.: Synth. React. Inorg. Met.-Org. Chem. 2000.30, 1835.
[43]	Nakamoto K.: Complexes of Amino acid, EDTA and Related Compounds. in Infrared and Raman Spectra of Inorganic and Coordination Compounds, 4th ed. pp. J. Wiley and Sons, New York. 1986. 4, 232-239.
[44]	Murdula B.V., Venkatanarayana G., Lingaiah P.: Ind. J. Chem. 1989. 28(A), 1011.
[45]	Reddy P.R., Radhika M., Manjula P.: J. Chem. Sci. 2005. 117, 239.
[46]	Yamuchi O., Odani A.: J. Am. Chem. Soc.1985. 107, 5938.
[47]	Mohanta H.N., Sahoo K.L.: Asian J. Chem. 1996, 8, 298.
[48]	Bailey R.A., Kozak S.L., Michelson T.W., Mills W.N.: Coord. Chem. Rev.1971. 6, 407.
[49]	Holm R.H., Cornor M.J.O.: Prog. Inorg. Chem. 1971. 14, 241.
[50]	Dash K.C., Mohanta H.N.: J. Inorg. Nucl. Chem.1977. 39, 1345.
[51]	Shivankar V.S., Vaidya R.B., Dharwadkar S.R., Thakkar N.V.: Syn. React. Inorg. Metal-Org. Chem. 2003 33, 1597.